HtrA1 serine protease inhibits signaling mediated by Tgfβ family proteins
نویسندگان
چکیده
منابع مشابه
Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
High temperature requirement protein A1 (HtrA1), a secreted serine protease of the HtrA family, is associated with a multitude of human diseases. However, the exact functions of HtrA1 in these diseases remain poorly understood. We seek to unravel the mechanisms of HtrA1 by elucidating its interactions with chemical or biological modulators. To this end, we screened a small molecule library of 5...
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HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological and pathological processes. In part, HTRA1 regulation occurs by inhibiting the TGF-β signaling pathway, however the mechanism of inhibition has not been fully defined. Previous studies have shown that HTRA1 is expressed in a variety of tissues, including sites of ske...
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nant type I receptor in vitro (references can be found The transforming growth factor b (TGFb) family of cytoin Massagué and Weis-Garcia, 1996). Phosphorylation kines regulates cell proliferation, differentiation, recogoccurs in a cluster of five serine and threonine residues nition, and death and figures prominently in the control in the GS domain, a highly conserved region next to the of deve...
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ژورنال
عنوان ژورنال: Development
سال: 2004
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.00999